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neuromuscular$52401$ - перевод на голландский
![Fig.1 A simple illustration of how two [[acetylcholine]] molecules bind to its receptive sites on the nicotinic receptor](https://commons.wikimedia.org/wiki/Special:FilePath/Acetylcholine nicotinic receptor binding.svg?width=200 "Fig.1 A simple illustration of how two [[acetylcholine]] molecules bind to its receptive sites on the nicotinic receptor")
![Fig.2 A simple illustration of how [[decamethonium]] binds to the nicotinic receptor. The onium heads bind to two separate subunits of the ion-channel](https://commons.wikimedia.org/wiki/Special:FilePath/Decamethonium binding acth-receptor.svg?width=200 "Fig.2 A simple illustration of how [[decamethonium]] binds to the nicotinic receptor. The onium heads bind to two separate subunits of the ion-channel")
![[[Mind Map]] showing a summary of '''Neuromuscular depolarizing agent'''](https://commons.wikimedia.org/wiki/Special:FilePath/Neuromusculardepolarizingagent.gif?width=200 "[[Mind Map]] showing a summary of '''Neuromuscular depolarizing agent'''")
![[[Mind Map]] showing a summary of '''Neuromuscular nondepolarizing agent'''](https://commons.wikimedia.org/wiki/Special:FilePath/Neuromuscularnondepolarizingagent.gif?width=200 "[[Mind Map]] showing a summary of '''Neuromuscular nondepolarizing agent'''")
![[[Mitochondrion]]}}](https://commons.wikimedia.org/wiki/Special:FilePath/Synapse diag4.png?width=200 "[[Mitochondrion]]}}")
Википедия
Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors.
In clinical use, neuromuscular block is used adjunctively to anesthesia to produce paralysis, firstly to paralyze the vocal cords, and permit intubation of the trachea, and secondly to optimize the surgical field by inhibiting spontaneous ventilation, and causing relaxation of skeletal muscles. Because the appropriate dose of neuromuscular-blocking drug may paralyze muscles required for breathing (i.e., the diaphragm), mechanical ventilation should be available to maintain adequate respiration.
Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and/or analgesics must also be given to prevent anesthesia awareness.
